Full publications list.

Selected Publications

2021 Publications

p53 and TDG are dominant in regulating the activity of the human de novo DNA methyltransferase DNMT3A on nucleosomes
Sandoval JE, Reich NO. J. Biol. Chem., 296 (2021), 100058

A novel class of selective non-nucleoside inhibitors of human DNA methyltransferase 3A
Huang S, Stillson NJ, Sandoval JE, Yung C, Reich NO. Bioorg. Med. Chem. Lett., 40 (2021), 127908

2020 Publications

Cell cycle regulated DNA methyltransferase: fluorescent tracking of a DNA strand-separation mechanism and identification of the responsible protein motif
Konttinen O, Carmody J, Pathuri S, Anderson K, Zhou X, Reich NO. Nucleic Acids Res., 48(20) (2020), 11589-11601

2019 Publications

The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site
Horton JR, Woodcock CB, Opot SB, Reich NO, Zhang X, Cheng X. Nat. Commun., 10(1) (2019), 4600

The R882H substitution in the human de novo DNA methyltransferase DNMT3A disrupts allosteric regulation by the tumor supressor p53
Sandoval JE, Reich NO. J. Bio. Chem., 294(48) (2019), 18207-18219

Mutations in the DNMT3A DNA methyltransferase in acute myeloid leukemia patients cause both loss and gain of function and differential regulation by protein partners
Sandoval JE, Huang YH, Muise A, Goodell MA, Reich NO. J. Bio. Chem., 294(13) (2019), 4898-4910

Shape Matters: Gold Nanoparticle Shape Impacts the Biological Activity of siRNA Delivery
Morgan E, Wupperfeld D, Morales DP, Reich NO. Bioconjugate Chem., 30(3) (2019), 853-860

2018 Publications

The highly specific, cell cycle\[Dash]regulated methyltransferase from Caulobacter crescentus relies on a novel DNA recognition mechanism
Reich NO, Dang E, Kurnik M, Pathuri S, Woodcock CB. J. Biol. Chem., 293(49) (2018), 19038-19046

2017 Publications

Caulobacter crescentus Cell Cycle-Regulated DNA Methyltransferase Uses a Novel Mechanism for Substrate Recognition
Woodcock CB, Yakubov AB, Reich NO. Biochemistry-US, 56(30) (2017), 3913-3922

Affinity-Based Assembly of Peptides on Plasmonic Nanoparticles Delivered Intracellularly with Light Activated Control
Morales DP, Wonderly WR, Huang X, McAdams M, Chron AB, Reich NO. Bioconjugate Chem., 28(7) (2017), 1816-1820

2016 Publications

Light-Patterned RNA Interference of 3D-Cultured Human Embryonic Stem Cells
Huang X, Hu Q, Lai Y, Morales DP, Clegg DO, Reich NO. Adv. Mater., 28(48) (2016), 10732-10737

2015 Publications

De novo DNA methyltransferase DNMT3A: Regulation of oligomeric state and mechanism of action in response to pH changes
Holz-Schietinger C, Reich NO. BBA-Gen. Subjects, 1850(6) (2015), 1131-1139

Targeted Intracellular Delivery of Proteins with Spatial and Temporal Control
Morales DP, Braun GB, Pallaoro A, Chen R, Huang X, Zasadzinski JA, Reich NO. Mol. Pharm., 12(2) (2015), 600-609

Light-activated RNA interference in human embryonic stem cells
Huang X, Hu Q, Braun GB, Pallaoro A, Morales DP, Zasadzinski JA, Clegg DO, Reich NO. Biomaterials, 63 (2015), 70-79

2014 Publications

Modular Plasmonic Nanocarriers for Efficient and Targeted Delivery of Cancer-Therapeutic siRNA
Huang X, Pallaoro A, Braun GB, Morales DP, Ogunyankin MO, Zasadzinski JA, Reich NO. Nano Lett., 14(4) (2014), 2046-2051

2012 Publications

RNA modulation of the human DNA methyltransferase 3A
Holz-Schietinger C, Reich NO. Nucleic Acids Res., 40(17) (2012), 8550-8557

Mutations in DNA Methyltransferase (DNMT3A) Observed in Acute Myeloid Leukemia Patients Disrupt Processive Methylation
Holz-Schietinger C, Matje DM, Reich NO. J. Bio. Chem., 287(37) (2012), 30941-30951

2011 Publications

Oligomerization of DNMT3A Controls the Mechanism of de Novo DNA Methylation
Holz-Schietinger C, Matje DM, Harrison MF, Reich NO. J. Bio. Chem., 286(48) (2011), 41479-41488

2010 Publications

Identification of a second DNA binding site in human DNA methyltransferase 3A by substrate inhibition and domain deletion
Purdy MM, Holz-Schietinger C, Reich NO. Arch. Biochem. Biophys., 498(1) (2010), 13-22

The Inherent Processivity of the Human de Novo Methyltransferase 3A (DNMT3A) Is Enhanced by DNMT3L
Holz-Schietinger C, Reich NO. J. Biol. Chem., 285(38) (2010), 29091-29100

2008 Publications

Enzyme-Directed Positioning of Nanoparticles on Large DNA Templates
Braun GB, Dietchtierow M, Wilkinson S, Schmidt F, Hüben M, Weinhold E, Reich NO. Bioconjugate Chem., 19(2) (2008), 476-479

2007 Publications

Specific and sensitive detection of nucleic acids and RNases using gold nanoparticle\[Dash]RNA\[Dash]fluorescent dye conjugates
Kim JH, Estabrook RA, Braun GB, Lee BR, Reich NO. Chem. Commun., (42) (2007), 4342

Chemically Patterned Microspheres for Controlled Nanoparticle Assembly in the Construction of SERS Hot Spots
Braun GB, Pavel I, Morrill AR, Seferos DS, Bazan GC, Reich NO, Moskovits M. J. Am. Chem. Soc., 129(25) (2007), 7760-7761

Detection of Sequence-Specific Protein-DNA Interactions via Surface Enhanced Resonance Raman Scattering
Bonham AJ, Braun GB, Pavel I, Moskovits M, Reich NO. J. Am. Chem. Soc., 129(47) (2007), 14572-14573

2006 Publications

Selective Inhibitors of Bacterial DNA Adenine Methyltransferases
Mashhoon N, Pruss C, Carroll M, Johnson PH, Reich NO. J. Biomol. Screen, 11(5) (2006), 497-510

2005 Publications

Controlled Spacing of Cationic Gold Nanoparticles by Nanocrown RNA
Koyfman AY, Braun GB, Magonov S, Chworos A, Reich NO, Jaeger L. J. Am. Chem. Soc., 127(34) (2005), 11886-11887

Gold Nanoparticle Decoration of DNA on Silicon
Braun GB, Inagaki K, Estabrook RA, Wood DK, Levy E, Cleland AN, Strouse GF, Reich NO. Langmuir, 21(23) (2005), 10699-10701